Olecol® is a natural ingredient derived from olive leaf that offers a safe and multi-target approach to blood lipid management. Olecol® has been clinically proven to decrease bad cholesterol (LDL) and triglycerides (TG), increase good cholesterol (HDL) and TG/HDL-c ratio, and even fight lipid oxidation.


Olecol® is a natural ingredient derived from olive leaves that is standardized for its high content of oleuropein, a bioactive phytonutrient unique to the olive tree. Additionally, Olecol® is highly water-soluble due to the special soluphenol extraction method. Olecol® is a safe and multi-target approach to blood lipid control by decreasing bad cholesterol (LDL) and triglycerides (TG), increasing good cholesterol (HDL) and TG/HDL-c ratio, and even fighting lipid oxidation.

Water soluble


Superior Bioavailability

Superior Bioavailability



Clinicaly proven

Clinically Proven

Triple action on blood lipid control

Triple action on blood lipid control

Clinically proven

The benefits of Olecol® have been assessed in three clinical studies, which have demonstrated the dual action of the ingredient: improved blood lipid control in both subjects with hypercholesterolemia and overweight + strong antioxidant properties.

Blood Lipid Control

A 12-month randomized, double-blind, placebo-controlled study was designed to investigate the effects of a daily dose of 250 mg Olecol® on subjects with elevated cholesterol levels. Olecol® showed a significant effect on blood lipid levels after the 12-month intervention. The levels of LDL cholesterol, total cholesterol and triglycerides were significantly decreased in the Olecol® group compared to the placebo group. Furthermore, a significant difference in the total cholesterol/HDL ratio between the Olecol® group and the placebo group was seen. This ratio predicts the subject’s risk of developing atherosclerosis, and by extension, cardiovascular diseases.

A second study was carried out to investigate triglycerides (TG) and TG/HDL-c ratio profiles in overweight subjects. The 4-week randomized, double-blind, placebo-controlled study with a daily dose of 250 mg Olecol® showed a significantly improved TG/HDL-c ratio in the group receiving Olecol® treatment compared to the placebo group. In addition, triglyceride levels tended to decrease after 4-week supplementation.

Blood Lipid Control

Antioxidant Properties

An oxidative control study, also carried out with a single dose of 250mg of Olecol®, measured 1) the oxidant status of the blood lipids and 2) the circulating levels of metabolites of the extract in plasma and urine of the participants. Olecol® showed to have antioxidant properties and protect from LDL oxidation. Oxidative stress leads to the production of damaging free radicals. These molecules have been shown to be linked to vascular inflammation, endothelial dysfunction, and subsequently to a high prevalence of cardiovascular diseases.

Mode of action

The mode of action of Olecol® is twofold. Olive polyphenols have been shown to increase cholesterol excretion:

  1. The liver is stimulated to secrete cholesterol into bile.
  2. The cholesterol levels in bile increase and is subsequently discharged into the duodenum.
  3. This leads to more excretion of cholesterol through the feces.

Secondly, a daily dose of 250 mg Olecol® has strong antioxidant properties. This leads to the protection of the HDL [good] cholesterol, and limits the oxidation of the LDL [bad] cholesterol – which is linked to an increased risk of CV events.

Olecol mode action

White paper

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Researched & developed by BioActor

Olecol® was researched and developed by BioActor, a Dutch life science company that develops health ingredients for functional foods, clinical nutrition, and dietary supplements.

Embedded in the Maastricht Health Campus, BioActor focuses on the core mission of bringing nutrition backed up by real science to consumers, helping them perform better and improve their health and well-being.

Find out more about BioActor, visit the website